Chromosome 8

Genes Linked with Cancer (103)

How to use this data table Click on the gene name for detailed information. Type in the Search box e.g. 'germline' or 'Breast Cancer' to search within Chromosome 8; or Sort by clicking on a column heading e.g. 'Gene'.

Gene Location Aliases Abnormalities Implicated in
PLAT 8p11.21 TPA, T-PA-Bladder Cancer
-Breast Cancer
-Lung Cancer
-Pancreatic Cancer
-Prostate Cancer
POLB 8p11.21 -Bladder Cancer
-Breast Cancer
-Cervical Cancer
-Colorectal Cancer
-Lung Cancer
-Pancreatic Cancer
-Transitional Cell Cancer of the Renal Pelvis and Ureter
HOOK3 8p11.21 HK3Somatic
Translocation
-Thyroid Cancer
IDO1 8p11.21 IDO, INDO, IDO-1-Bladder Cancer
-Cervical Cancer
-Colorectal Cancer
-Lung Cancer
-Non-Hodgkin Lymphoma
-Ovarian Cancer
-Stomach Cancer
-Thyroid Cancer
IKBKB 8p11.21 IKK2, IKKB, IMD15, NFKBIKB, IKK-beta-Kaposi Sarcoma
-Prostate Cancer
-Skin Cancer
-Thyroid Cancer
SFRP1 8p11.21 FRP, FRP1, FrzA, FRP-1, SARP2-Breast Cancer
-Cervical Cancer
-Colorectal Cancer
-Liver Cancer
KAT6A 8p11.21 MOZ, MRD32, MYST3, MYST-3, ZNF220, RUNXBP2, ZC2HC6ASomatic-Acute Myeloid Leukaemia
-Haematological Malignancies
-Leukaemia
ADAM9 8p11.22 MCMP, MDC9, CORD9, Mltng-Breast Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Pancreatic Cancer
-Prostate Cancer
STAR 8p11.23 STARD1-Bladder Cancer
-Breast Cancer
-Colorectal Cancer
-Lung Cancer
-Ovarian Cancer
-Stomach Cancer
EIF4EBP1 8p11.23 BP-1, 4EBP1, 4E-BP1, PHAS-I-Bladder Cancer
-Breast Cancer
NSD3 8p11.23 KMT3F, KMT3G, WHISTLE, WHSC1L1, pp14328Somatic-Bladder Cancer
-Breast Cancer
-Leukaemia
-Lung Cancer
-Lung Cancer, Non-Small Cell
FGFR1 8p11.23 CEK, FLG, HH2, OGD, ECCL, FLT2, KAL2, BFGFR, CD331, FGFBR, FLT-2, HBGFR, N-SAM, FGFR-1, HRTFDS, bFGF-R-1Somatic-Bladder Cancer
-Brain Tumours, Childhood
-Breast Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Myeloproliferative Disorders
NRG1 8p12 GGF, HGL, HRG, NDF, ARIA, GGF2, HRG1, HRGA, SMDF, MST131, MSTP131, NRG1-IT2-Bladder Cancer
-Breast Cancer
-Lung Cancer
PPP2CB 8p12 PP2CB, PP2Abeta-Bladder Cancer
-Breast Cancer
-Cervical Cancer
-Colorectal Cancer
-Lung Cancer
-Prostate Cancer
-Skin Cancer
-Transitional Cell Cancer of the Renal Pelvis and Ureter
-Wilms Tumour
DUSP4 8p12 TYP, HVH2, MKP2, MKP-2-Breast Cancer
-Colorectal Cancer
-Lung Cancer
-Stomach Cancer
WRN 8p12 RECQ3, RECQL2, RECQL3Germline-Bladder Cancer
-Bloom Syndrome
-Breast Cancer
-Colorectal Cancer
-Stomach Cancer
CLU 8p21.1 CLI, AAG4, APOJ, CLU1, CLU2, KUB1, SGP2, APO-J, SGP-2, SP-40, TRPM2, TRPM-2, NA1/NA2-Breast Cancer
-Cervical Cancer
-Ovarian Cancer
-Prostate Cancer
-Testicular Cancer
ADAM7 8p21.2 EAPI, GP83, GP-83, ADAM 7, ADAM-7Somatic-Melanoma
NKX3-1 8p21.2 NKX3, BAPX2, NKX3A, NKX3.1-Prostate Cancer
BNIP3L 8p21.2 NIX, BNIP3a-Breast Cancer
-Kidney Cancer
-Liver Cancer
-Pancreatic Cancer
STC1 8p21.2 STC-Breast Cancer
-Colorectal Cancer
-Liver Cancer
-Lung Cancer
NEFL 8p21.2 NFL, NF-L, NF68, CMT1F, CMT2E, PPP1R110-Bladder Cancer
-Brain Tumours, Childhood
-Breast Cancer
-Lung Cancer
-Neuroblastoma
-Prostate Cancer
LZTS1 8p21.3 F37, FEZ1-Breast Cancer
-Eye Cancer
-Lung Cancer
-Ovarian Cancer
-Prostate Cancer
TNFRSF10B 8p21.3 DR5, CD262, KILLER, TRICK2, TRICKB, ZTNFR9, TRAILR2, TRICK2A, TRICK2B, TRAIL-R2, KILLER/DR5-Breast Cancer
-Cervical Cancer
-Colorectal Cancer
-Head and Neck Cancers
-Lung Cancer
-Prostate Cancer
RHOBTB2 8p21.3 DBC2-Bladder Cancer
-Breast Cancer
-Head and Neck Cancers
-Multiple Myeloma
TNFRSF10A 8p21.3 DR4, APO2, CD261, TRAILR1, TRAILR-1-Breast Cancer
-Colorectal Cancer
-Lung Cancer
-Pancreatic Cancer
-Prostate Cancer
-von Hippel-Lindau Disease
DOK2 8p21.3 p56DOK, p56dok-2-Acute Lymphocytic Leukaemia (ALL)
-Acute Myeloid Leukaemia
-Leukaemia
-Lung Cancer
-Stomach Cancer
TNFRSF10D 8p21.3 DCR2, CD264, TRUNDD, TRAILR4, TRAIL-R4-Breast Cancer
-Lung Cancer
-Neuroblastoma
-Prostate Cancer
-von Hippel-Lindau Disease
TNFRSF10C 8p21.3 LIT, DCR1, TRID, CD263, TRAILR3, TRAIL-R3, DCR1-TNFR-Breast Cancer
-Colorectal Cancer
-Liver Cancer
-Neuroblastoma
-Pancreatic Cancer
-Prostate Cancer
-Skin Cancer
LOXL2 8p21.3 LOR, LOR2, WS9-14-Breast Cancer
-Colorectal Cancer
-Esophageal Cancer
-Liver Cancer
-Lung Cancer
-Skin Cancer
ASAH1 8p22 AC, PHP, ASAH, PHP32, ACDase, SMAPME-Lung Cancer
-Lung Cancer, Non-Small Cell
-Melanoma
-Prostate Cancer
-Thyroid Cancer
PDGFRL 8p22 PDGRL, PRLTS-Breast Cancer
-Esophageal Cancer
-Kidney Cancer
-Ovarian Cancer
MTUS1 8p22 ATBP, ATIP, ICIS, MP44, ATIP3, MTSG1-Breast Cancer
-Colorectal Cancer
-Prostate Cancer
NAT2 8p22 AAC2, PNAT, NAT-2-Bladder Cancer
-Breast Cancer
-Colorectal Cancer
-Laryngeal Cancer
-Lung Cancer
-Oral Cavity Cancer
-Thyroid Cancer
MSR1 8p22 SRA, SR-A, CD204, SR-AI, phSR1, phSR2, SCARA1, SR-AII, SR-AIII-Prostate Cancer
NAT1 8p22 AAC1, MNAT, NATI, NAT-1-Bladder Cancer
-Breast Cancer
-Colorectal Cancer
-Lung Cancer
-Pancreatic Cancer
DLC1 8p22 HP, ARHGAP7, STARD12, p122-RhoGAPSomatic
Deletion
Underexpressed
Many cancer types including:
-Breast Cancer
-Liver Cancer
-Lung Cancer
-Nasopharyngeal Cancer
-Prostate Cancer
PCM1 8p22 PTC4, RET/PCM-1Somatic-Breast Cancer
-Chronic Myelogenous Leukemia
-Colorectal Cancer
-Haematological Malignancies
-Leukaemia
-Lung Cancer
-Myeloproliferative Disorders
-Ovarian Cancer
-Thyroid Cancer
GATA4 8p23.1 TOF, ASD2, VSD1, TACHD-Breast Cancer
-Colorectal Cancer
-Lung Cancer
-Ovarian Cancer
-Rectal Cancer
-Stomach Cancer
CTSB 8p23.1 APPS, CPSB-Breast Cancer
-Cervical Cancer
-Esophageal Cancer
-Prostate Cancer
-Stomach Cancer
-Thyroid Cancer
TNKS 8p23.1 TIN1, ARTD5, PARPL, TINF1, TNKS1, pART5, PARP5A, PARP-5a-Bladder Cancer
-Brain Tumours, Childhood
-Breast Cancer
-Lung Cancer
-Ovarian Cancer
-Stomach Cancer
PINX1 8p23.1 LPTL, LPTS-Breast Cancer
-Cervical Cancer
-Esophageal Cancer
-Liver Cancer
-Prostate Cancer
-Stomach Cancer
MIR124-1 8p23.1 MIR124A, MIR124A1, MIRN124-1, MIRN124A1, mir-124-1-Brain Tumours, Childhood
-Breast Cancer
-Cervical Cancer
-Haematological Malignancies
-Liver Cancer
-Stomach Cancer
ANGPT2 8p23.1 ANG2, AGPT2-Breast Cancer
-Liver Cancer
-Neuroblastoma
-Stomach Cancer
CSMD1 8p23.2 PPP1R24-Colorectal Cancer
-Head and Neck Cancers
-Liver Cancer
-Oral Cavity Cancer
-Prostate Cancer
-Skin Cancer
FEZ1 11q24.2 UNC-76-Bladder Cancer
-Breast Cancer
-Esophageal Cancer
-Prostate Cancer
-Stomach Cancer
PRKDC 8q11.21 HYRC, p350, DNAPK, DNPK1, HYRC1, IMD26, XRCC7, DNA-PKcs-Bladder Cancer
-Brain Stem Glioma, Childhood
-Brain Tumours, Childhood
-Breast Cancer
-Lung Cancer
CEBPD 8q11.21 CELF, CRP3, C/EBP-delta, NF-IL6-beta-Acute Myeloid Leukaemia
-Breast Cancer
-Liver Cancer
-Prostate Cancer
-Urinary System Cancers
SNAI2 8q11.21 SLUG, WS2D, SLUGH, SLUGH1, SNAIL2-Brain Tumours, Childhood
-Breast Cancer
-Lung Cancer
-Ovarian Cancer
-Prostate Cancer
MCM4 8q11.21 NKCD, CDC21, CDC54, NKGCD, hCdc21, P1-CDC21-Bladder Cancer
-Cervical Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Melanoma
-Nasopharyngeal Cancer
-Osteosarcoma
-Skin Cancer
-Stomach Cancer
SOX17 8q11.23 VUR3-Breast Cancer
-Cancer Screening
-Esophageal Cancer
-Testicular Cancer
TCEA1 8q11.23 SII, TCEA, TF2S, GTF2S, TFIISSomatic-Salivary Gland Cancer
PLAG1 8q12.1 PSA, SGPA, ZNF912Somatic-Adenoid Cystic Carcinoma
-Salivary Gland Cancer
LYN 8q12.1 JTK8, p53Lyn, p56Lyn-Breast Cancer
-Chronic Lymphocytic Leukemia
-Chronic Myelogenous Leukemia
-Lung Cancer
MOS 8q12.1 MSV-Breast Cancer
-Lung Cancer
-Salivary Gland Cancer
-Stomach Cancer
-Wilms Tumour
CHCHD7 8q12.1 COX23Somatic-Leukaemia
-Lung Cancer
-Salivary Gland Cancer
TTPA 8q12.3 ATTP, AVED, TTP1, alphaTTP-Breast Cancer
-Prostate Cancer
-Uterine Sarcoma
COPS5 8q13.1 CSN5, JAB1, SGN5, MOV-34-Breast Cancer
-Liver Cancer
-Nasopharyngeal Cancer
MYBL1 8q13.1 AMYB, A-MYB-Brain Stem Glioma, Childhood
-Brain Tumours, Childhood
-Chronic Lymphocytic Leukemia
SULF1 8q13.2-q13.3 SULF-1-Breast Cancer
-Liver Cancer
-Ovarian Cancer
-Pancreatic Cancer
-Stomach Cancer
NCOA2 8q13.3 SRC2, TIF2, GRIP1, KAT13C, NCoA-2, bHLHe75Somatic-Acute Myeloid Leukaemia
-Breast Cancer
-Chondrosarcoma, Mesenchymal
-Prostate Cancer
-Soft Tissue Sarcoma
TPD52 8q21.13 D52, N8L, PC-1, PrLZ, hD52-Breast Cancer
-Prostate Cancer
FABP5 8q21.13 EFABP, KFABP, E-FABP, PAFABP, PA-FABP-Bladder Cancer
-Breast Cancer
-Liver Cancer
-Prostate Cancer
-Vulvar Cancer
IL7 8q21.13 IL-7-Acute Lymphocytic Leukaemia (ALL)
-Bone Cancer (primary)
-Prostate Cancer
HEY1 8q21.13 CHF2, OAF1, HERP2, HESR1, HRT-1, hHRT1, BHLHb31Somatic-Bone Cancer (primary)
-Brain Tumours, Childhood
-Breast Cancer
-Chondrosarcoma, Mesenchymal
-Lung Cancer
E2F5 8q21.2 E2F-5-Breast Cancer
-Ovarian Cancer
-Prostate Cancer
NBN 8q21.3 ATV, NBS, P95, NBS1, AT-V1, AT-V2Germline-Breast Cancer
-Cervical Cancer
-Ovarian Cancer
-Prostate Cancer
-Stomach Cancer
-Wilms Tumour
RUNX1T1 8q21.3 CDR, ETO, MTG8, AML1T1, ZMYND2, CBFA2T1, AML1-MTG8Somatic
Translocation
-Acute Myeloid Leukaemia
-Leukaemia
MTDH 8q22.1 3D3, AEG1, AEG-1, LYRIC, LYRIC/3D3-Brain Tumours, Childhood
-Breast Cancer
-Cervical Cancer
-Liver Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Ovarian Cancer
-Skin Cancer
-Stomach Cancer
CCNE2 8q22.1 CYCE2-Breast Cancer
-Eye Cancer
-Lung Cancer
-Small Cell Lung Cancer
-Nasopharyngeal Cancer
-Ovarian Cancer
-Prostate Cancer
-Stomach Cancer
-Vulvar Cancer
CDH17 8q22.1 HPT1, CDH16, HPT-1-Colorectal Cancer
-Liver Cancer
-Lung Cancer
-Stomach Cancer
LAPTM4B 8q22.1 LC27, LAPTM4beta-Breast Cancer
-Cervical Cancer
-Gallbladder Cancer
-Liver Cancer
-Lung Cancer
-Pituitary Tumors
-Prostate Cancer
-Rectal Cancer
-Stomach Cancer
TP53INP1 8q22.1 SIP, Teap, p53DINP1, TP53DINP1, TP53INP1A, TP53INP1B-Breast Cancer
-Cervical Cancer
-Esophageal Cancer
-Liver Cancer
-Pancreatic Cancer
-Stomach Cancer
COX6C 8q22.2 Somatic-Breast Cancer
-Esophageal Cancer
-Uterine Sarcoma
YWHAZ 8q22.3 HEL4, YWHAD, KCIP-1, HEL-S-3, HEL-S-93, 14-3-3-zeta-Bladder Cancer
-Bone Cancer (primary)
-Breast Cancer
-Cervical Cancer
-Liver Cancer
-Lung Cancer
-Prostate Cancer
-Stomach Cancer
RRM2B 8q22.3 P53R2, MTDPS8A, MTDPS8B-Breast Cancer
-Cervical Cancer
-Colorectal Cancer
-Esophageal Cancer
-Lung Cancer
-Prostate Cancer
-Skin Cancer
-Urinary System Cancers
BAALC 8q22.3 -Acute Myeloid Leukaemia
-Leukaemia
EIF3E 8q23.1 INT6, EIF3S6, EIF3-P48, eIF3-p46-Breast Cancer
-Colorectal Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Melanoma
-Prostate Cancer
ANGPT1 8q23.1 AGP1, AGPT, ANG1-Astrocytoma, Childhood
-Brain Tumours, Childhood
-Breast Cancer
-Liver Cancer
-Stomach Cancer
EBAG9 8q23.2 EB9, PDAF-Breast Cancer
-Endometrial Cancer
-Liver Cancer
-Ovarian Cancer
-Uterine Sarcoma
TRPS1 8q23.3 GC79, LGCR-Bone Cancer (primary)
-Breast Cancer
-Prostate Cancer
EXT1 8q24.11 EXT, LGS, TTV, LGCR, TRPS2Germline-Chondrosarcoma
-Multiple Hereditary Exostoses
-Osteosarcoma
RAD21 8q24.11 HR21, MCD1, NXP1, SCC1, CDLS4, hHR21, HRAD21-Acute Myeloid Leukaemia
-Breast Cancer
TNFRSF11B 8q24.12 OPG, TR1, OCIF, PDB5-Breast Cancer
-Multiple Myeloma
-Osteosarcoma
-Prostate Cancer
NOV 8q24.12 CCN3, NOVh, IBP-9, IGFBP9, IGFBP-9-Bone Cancer (primary)
-Breast Cancer
-Liver Cancer
-Pancreatic Cancer
-Rhabdomyosarcoma
-Wilms Tumour
RNF139 8q24.13 RCA1, TRC8, HRCA1
Translocation
-Kidney Cancer
HAS2 8q24.13 -Bone Cancer (primary)
-Breast Cancer
-Ovarian Cancer
MTSS1 8q24.13 MIM, MIMA, MIMB-Bladder Cancer
-Breast Cancer
-Colorectal Cancer
-Liver Cancer
-Lung Cancer
-Prostate Cancer
-Stomach Cancer
PVT1 8q24.21 MYC, LINC00079, NCRNA00079, onco-lncRNA-100-Breast Cancer
-Lung Cancer
-Pancreatic Cancer
-Prostate Cancer
-Stomach Cancer
MYC 8q24.21 MRTL, MYCC, c-Myc, bHLHe39Somatic
Amplification
-Breast Cancer
-Colorectal Cancer
-Liver Cancer
-Lung Cancer
-Medulloblastoma
-Skin Cancer
-Stomach Cancer
CCDC26 8q24.21 RAM-Acute Myeloid Leukaemia
-Astrocytoma, Childhood
-Brain and CNS Tumours
-Brain Stem Glioma, Childhood
-Brain Tumours, Childhood
NDRG1 8q24.22 GC4, RTP, DRG1, NDR1, NMSL, TDD5, CAP43, CMT4D, DRG-1, HMSNL, RIT42, TARG1, PROXY1Somatic-Breast Cancer
-Cervical Cancer
-Colorectal Cancer
-Liver Cancer
-Lung Cancer
-Pancreatic Cancer
-Prostate Cancer
-Skin Cancer
WISP1 8q24.22 CCN4, WISP1c, WISP1i, WISP1tc-Breast Cancer
-Colorectal Cancer
-Lung Cancer
-Oral Cavity Cancer
SCRIB 8q24.3 CRIB1, SCRB1, SCRIB1, Vartul-Breast Cancer
-Cervical Cancer
PTK2 8q24.3 FAK, FADK, FAK1, FRNK, PPP1R71, p125FAK, pp125FAK-Brain Tumours, Childhood
-Breast Cancer
-Liver Cancer
-Lung Cancer
-Stomach Cancer
PTP4A3 8q24.3 PRL3, PRL-3, PRL-R-Cervical Cancer
-Colorectal Cancer
-Eye Cancer
-Liver Cancer
-Stomach Cancer
HSF1 8q24.3 HSTF1-Breast Cancer
-Liver Cancer
-Melanoma
CYP11B2 8q24.3 CPN2, ALDOS, CYP11B, CYP11BL, CYPXIB2, P450C18, P-450C18, P450aldo-Adrenocortical Cancer
ADGRB1 8q24.3 BAI1, GDAIF-Bladder Cancer
-Brain Stem Glioma, Childhood
-Brain Tumours, Childhood
-Colorectal Cancer
-Lung Cancer
-Lung Cancer, Non-Small Cell
-Stomach Cancer
CYP11B1 8q24.3 FHI, CPN1, CYP11B, P450C11-Adrenocortical Cancer
AGO2 8q24.3 PPD, Q10, CASC7, EIF2C2, LINC00980-Breast Cancer
-Liver Cancer
-Lung Cancer
-Small Cell Lung Cancer
-Prostate Cancer
PSCA 8q24.3 PRO232-Pancreatic Cancer
-Prostate Cancer
-Stomach Cancer
RECQL4 8q24.3 RECQ4Germline-Rothmund-Thomson Syndrome
-Breast Cancer
-Cervical Cancer
-Laryngeal Cancer
-Osteosarcoma
-Non-Melanoma Skin Cancer (NMSC)

Structural Abnormalities

Selected list of common recurrent structural abnormalities - Chromosome 8:

This is a highly selective list aiming to capture structural abnormalies which are frequesnt and/or significant in relation to diagnosis, prognosis, and/or characterising specific cancers. For a much more extensive list see the Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer.

Further Resources (3 links)

Disclaimer: This site is for educational purposes only; it can not be used in diagnosis or treatment.

Cite this page: Cotterill SJ. Chromosome 8, Cancer Genetics Web: http://www.cancer-genetics.org/clinkc08.htm Accessed:

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