ZNF750

Gene Summary

Gene:ZNF750; zinc finger protein 750
Aliases: ZFP750
Location:17q25.3
Summary:This gene encodes a protein with a nuclear localization site and a C2H2 zinc finger domain. Mutations in this gene have been associated with seborrhea-like dermatitis with psoriasiform elements. [provided by RefSeq, Jul 2008]
Databases:OMIM, VEGA, HGNC, Ensembl, GeneCard, Gene
Protein:zinc finger protein 750
HPRD
Source:NCBIAccessed: 17 August, 2015

Ontology:

What does this gene/protein do?
Show (7)

Cancer Overview

Research Indicators

Publications Per Year (1990-2015)
Graph generated 17 August 2015 using data from PubMed using criteria.

Literature Analysis

Mouse over the terms for more detail; many indicate links which you can click for dedicated pages about the topic.

  • Genome, Human
  • Molecular Sequence Data
  • Cytidine Deaminase
  • Gene Knockdown Techniques
  • DNA Sequence Analysis
  • CBX8 protein, human
  • Tumor Suppressor Proteins
  • Mutation
  • Esophageal Cancer
  • Immunoblotting
  • RT-PCR
  • China
  • LIM Domain Proteins
  • Genetic Vectors
  • Exome
  • ZNF750
  • AJUBA protein, human
  • Ubiquitin Thiolesterase
  • PIK3CA protein, human
  • High-Throughput Nucleotide Sequencing
  • Squamous Cell Carcinoma
  • Immunohistochemistry
  • DNA Copy Number Variations
  • Microscopy, Fluorescence
  • thiazolyl blue
  • Chromosome 17
  • Signal Transduction
  • Base Sequence
  • RTPCR
  • CREBBP
  • BAP1
  • Transcription Factors
  • CREB-Binding Protein
  • FISH
  • exportin 1 protein
  • Polycomb-Group Proteins
  • patched receptors
  • Ubiquitin-Protein Ligases
  • apolipoprotein B mRNA editing enzyme
  • Thiazoles
Tag cloud generated 17 August, 2015 using data from PubMed, MeSH and CancerIndex

Specific Cancers (1)

Data table showing topics related to specific cancers and associated disorders. Scope includes mutations and abnormal protein expression.

Entity Topic PubMed Papers
Esophageal CancerZNF750 mutation in Esophageal Cancer
Lin DC, et al (2014) reported mutation of ZNF750 as part of sequenced whole exomes (WES) study of genomic and molecular characterization of esophageal squamous cell carcinoma. 20 tumours were analysed in an initial 'discovery' cohort, and then a further 119 samples to validate. They found that ZNF750 was focally deleted in 3.4% of ESCC tumors, and ZNF750 mRNA expression was lower in esophageal tumors compared with normal tissue.
View Publications2

Note: list is not exhaustive. Number of papers are based on searches of PubMed (click on topic title for arbitrary criteria used).

Latest Publications: ZNF750 (cancer-related)

Zhang L, Zhou Y, Cheng C, et al.
Genomic analyses reveal mutational signatures and frequently altered genes in esophageal squamous cell carcinoma.
Am J Hum Genet. 2015; 96(4):597-611 [PubMed] Free Access to Full Article Related Publications
Esophageal squamous cell carcinoma (ESCC) is one of the most common cancers worldwide and the fourth most lethal cancer in China. However, although genomic studies have identified some mutations associated with ESCC, we know little of the mutational processes responsible. To identify genome-wide mutational signatures, we performed either whole-genome sequencing (WGS) or whole-exome sequencing (WES) on 104 ESCC individuals and combined our data with those of 88 previously reported samples. An APOBEC-mediated mutational signature in 47% of 192 tumors suggests that APOBEC-catalyzed deamination provides a source of DNA damage in ESCC. Moreover, PIK3CA hotspot mutations (c.1624G>A [p.Glu542Lys] and c.1633G>A [p.Glu545Lys]) were enriched in APOBEC-signature tumors, and no smoking-associated signature was observed in ESCC. In the samples analyzed by WGS, we identified focal (<100 kb) amplifications of CBX4 and CBX8. In our combined cohort, we identified frequent inactivating mutations in AJUBA, ZNF750, and PTCH1 and the chromatin-remodeling genes CREBBP and BAP1, in addition to known mutations. Functional analyses suggest roles for several genes (CBX4, CBX8, AJUBA, and ZNF750) in ESCC. Notably, high activity of hedgehog signaling and the PI3K pathway in approximately 60% of 104 ESCC tumors indicates that therapies targeting these pathways might be particularly promising strategies for ESCC. Collectively, our data provide comprehensive insights into the mutational signatures of ESCC and identify markers for early diagnosis and potential therapeutic targets.

Lin DC, Hao JJ, Nagata Y, et al.
Genomic and molecular characterization of esophageal squamous cell carcinoma.
Nat Genet. 2014; 46(5):467-73 [PubMed] Free Access to Full Article Related Publications
Esophageal squamous cell carcinoma (ESCC) is prevalent worldwide and particularly common in certain regions of Asia. Here we report the whole-exome or targeted deep sequencing of 139 paired ESCC cases, and analysis of somatic copy number variations (SCNV) of over 180 ESCCs. We identified previously uncharacterized mutated genes such as FAT1, FAT2, ZNF750 and KMT2D, in addition to those already known (TP53, PIK3CA and NOTCH1). Further SCNV evaluation, immunohistochemistry and biological analysis suggested their functional relevance in ESCC. Notably, RTK-MAPK-PI3K pathways, cell cycle and epigenetic regulation are frequently dysregulated by multiple molecular mechanisms in this cancer. Our approaches also uncovered many druggable candidates, and XPO1 was further explored as a therapeutic target because it showed both gene mutation and protein overexpression. Our integrated study unmasks a number of novel genetic lesions in ESCC and provides an important molecular foundation for understanding esophageal tumors and developing therapeutic targets.

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Cite this page: Cotterill SJ. ZNF750, Cancer Genetics Web: http://www.cancer-genetics.org/ZNF750.htm Accessed:

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This page in Cancer Genetics Web by Simon Cotterill is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
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