Gene Summary

Gene:TPM3; tropomyosin 3
Aliases: TM3, TM5, TRK, CFTD, NEM1, TM-5, TM30, CAPM1, TM30nm, TPMsk3, hscp30, HEL-189, HEL-S-82p, OK/SW-cl.5
Summary:This gene encodes a member of the tropomyosin family of actin-binding proteins. Tropomyosins are dimers of coiled-coil proteins that provide stability to actin filaments and regulate access of other actin-binding proteins. Mutations in this gene result in autosomal dominant nemaline myopathy and other muscle disorders. This locus is involved in translocations with other loci, including anaplastic lymphoma receptor tyrosine kinase (ALK) and neurotrophic tyrosine kinase receptor type 1 (NTRK1), which result in the formation of fusion proteins that act as oncogenes. There are numerous pseudogenes for this gene on different chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
Databases:OMIM, VEGA, HGNC, Ensembl, GeneCard, Gene
Protein:tropomyosin alpha-3 chain
Source:NCBIAccessed: 28 February, 2015


What does this gene/protein do?
Show (12)

Cancer Overview

Research Indicators

Publications Per Year (1990-2015)
Graph generated 28 February 2015 using data from PubMed using criteria.

Literature Analysis

Mouse over the terms for more detail; many indicate links which you can click for dedicated pages about the topic.

  • Cell Proliferation
  • Oncogene Fusion Proteins
  • Lung Cancer
  • Brain-Derived Neurotrophic Factor
  • Western Blotting
  • NTRK1
  • Cancer Gene Expression Regulation
  • Messenger RNA
  • Thyroid Cancer
  • Translocation
  • Signal Transduction
  • Receptor Protein-Tyrosine Kinases
  • Neoplastic Cell Transformation
  • NTRK2
  • Apoptosis
  • Xenograft Models
  • Base Sequence
  • Neoplasm Metastasis
  • Molecular Sequence Data
  • Neoplasm Proteins
  • Immunohistochemistry
  • Adolescents
  • Electrophoresis, Gel, Two-Dimensional
  • Gene Rearrangement
  • Chromosome 2
  • Tumor Markers
  • Mutation
  • Breast Cancer
  • Gene Expression Profiling
  • Cell Movement
  • Lymphoma, Large-Cell, Anaplastic
  • Receptors, Nerve Growth Factor
  • Neoplasm Invasiveness
  • Ukraine
  • Chromosome 1
  • Protein-Tyrosine Kinases
  • Cancer DNA
  • Childhood Cancer
  • Adenocarcinoma
  • Amino Acid Sequence
Tag cloud generated 28 February, 2015 using data from PubMed, MeSH and CancerIndex

Specific Cancers (3)

Data table showing topics related to specific cancers and associated disorders. Scope includes mutations and abnormal protein expression.

Note: list is not exhaustive. Number of papers are based on searches of PubMed (click on topic title for arbitrary criteria used).

Latest Publications: TPM3 (cancer-related)