|Gene:||TPM3; tropomyosin 3|
|Aliases:||TM3, TM5, TRK, CFTD, NEM1, TM-5, TM30, CAPM1, TM30nm, TPMsk3, hscp30, HEL-189, HEL-S-82p, OK/SW-cl.5|
|Summary:||This gene encodes a member of the tropomyosin family of actin-binding proteins. Tropomyosins are dimers of coiled-coil proteins that provide stability to actin filaments and regulate access of other actin-binding proteins. Mutations in this gene result in autosomal dominant nemaline myopathy and other muscle disorders. This locus is involved in translocations with other loci, including anaplastic lymphoma receptor tyrosine kinase (ALK) and neurotrophic tyrosine kinase receptor type 1 (NTRK1), which result in the formation of fusion proteins that act as oncogenes. There are numerous pseudogenes for this gene on different chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]|
|Databases:||OMIM, VEGA, HGNC, Ensembl, GeneCard, Gene|
|Protein:||tropomyosin alpha-3 chain|
|Source:||NCBIAccessed: 28 February, 2015|
What does this gene/protein do?
Mouse over the terms for more detail; many indicate links which you can click for dedicated pages about the topic.
Data table showing topics related to specific cancers and associated disorders. Scope includes mutations and abnormal protein expression.
|Breast Cancer||TPM3 and Breast Cancer||View Publications||11|
|Lung Cancer||TPM3 and Lung Cancer||View Publications||12|
|Thyroid Cancer||TPM3 and Thyroid Cancer||View Publications||9|
Note: list is not exhaustive. Number of papers are based on searches of PubMed (click on topic title for arbitrary criteria used).