Down Syndrome and Cancer

Overview

Literature Analysis

Mouse over the terms for more detail; many indicate links which you can click for dedicated pages about the topic.

  • Infant
  • Neoplastic Cell Transformation
  • Chromosome 21
  • Remission Induction
  • Myeloid Leukemia
  • Core Binding Factor Alpha 2 Subunit
  • Chromosomes, Human, 21-22 and Y
  • Acute Myeloid Leukaemia
  • Down Syndrome
  • Chromosome Aberrations
  • DNA Mutational Analysis
  • Follow-Up Studies
  • Oncogene Fusion Proteins
  • JAK2
  • Translocation
  • Genetic Predisposition
  • Adolescents
  • Karyotyping
  • Erythroid-Specific DNA-Binding Factors
  • Newborns
  • Pregnancy
  • Chromosome Disorders
  • Risk Factors
  • Bone Marrow
  • Alzheimer Disease
  • Polymerase Chain Reaction
  • X-Rays
  • Gene Deletion
  • Leukaemia
  • ETS2
  • Mosaicism
  • Leukemia, Megakaryoblastic, Acute
  • Mutation
  • DNA-Binding Proteins
  • Childhood Cancer
  • FISH
  • RBM15
  • GATA1
  • Aneuploidy
  • Base Sequence
  • Sensitivity and Specificity
Tag cloud generated 29 August, 2019 using data from PubMed, MeSH and CancerIndex

Mutated Genes and Abnormal Protein Expression (8)

How to use this data tableClicking on the Gene or Topic will take you to a separate more detailed page. Sort this list by clicking on a column heading e.g. 'Gene' or 'Topic'.

GeneLocationAliasesNotesTopicPapers
GATA1 Xp11.23 GF1, GF-1, NFE1, XLTT, ERYF1, NF-E1, XLANP, XLTDA, GATA-1 -GATA1 and Down Syndrome
 223
JAK2 9p24.1 JTK10, THCYT3 -JAK2 mutations in Down syndrome-associated ALL
 17
ETS2 21q22.2 ETS2IT1 -ETS2 and Down Syndrome
 10
CRLF2 Xp22.3; Yp11.3 CRL2, TSLPR, CRLF2Y -CRLF2 and Down Syndrome
 8
P2RY8 Xp22.33; Yp11.3 P2Y8 -P2RY8 and Down Syndrome
 6
CHAT 10q11.23 CMS6, CMS1A, CMS1A2, CHOACTASE -CHAT and Down Syndrome
 6
MRTFA 22q13.1-q13.2 MAL, MKL, BSAC, MKL1, MRTF-A -MKL1 and Down Syndrome
 4
RBM15 1p13.3 OTT, OTT1, SPEN -RBM15 and Down Syndrome
 3

Note: list is not exhaustive. Number of papers are based on searches of PubMed (click on topic title for arbitrary criteria used).

Trisomy 21 (1 links)