|Gene:||TP63; tumor protein p63|
|Aliases:||AIS, KET, LMS, NBP, RHS, p40, p51, p63, EEC3, OFC8, p73H, p73L, SHFM4, TP53L, TP73L, p53CP, TP53CP, B(p51A), B(p51B)|
|Summary:||This gene encodes a member of the p53 family of transcription factors. The functional domains of p53 family proteins include an N-terminal transactivation domain, a central DNA-binding domain and an oligomerization domain. Alternative splicing of this gene and the use of alternative promoters results in multiple transcript variants encoding different isoforms that vary in their functional properties. These isoforms function during skin development and maintenance, adult stem/progenitor cell regulation, heart development and premature aging. Some isoforms have been found to protect the germline by eliminating oocytes or testicular germ cells that have suffered DNA damage. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3); split-hand/foot malformation 4 (SHFM4); ankyloblepharon-ectodermal defects-cleft lip/palate; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth); limb-mammary syndrome; Rap-Hodgkin syndrome (RHS); and orofacial cleft 8. [provided by RefSeq, Aug 2016]|
|Databases:||OMIM, HGNC, Ensembl, GeneCard, Gene|
|Protein:||tumor protein 63|
|Source:||NCBIAccessed: 01 September, 2019|
What does this gene/protein do?
Mouse over the terms for more detail; many indicate links which you can click for dedicated pages about the topic.
Data table showing topics related to specific cancers and associated disorders. Scope includes mutations and abnormal protein expression.
|Head and Neck Cancers||TP63 and Head and Neck Cancers||View Publications||96|
|Lung Cancer||TP63 and Lung Cancer||View Publications||65|
|Breast Cancer||TP63 and Breast Cancer||View Publications||40|
|Bladder Cancer||TP63 and Bladder Cancer||View Publications||29|
|Eye Cancer||TP63 and Uveal Neoplasms||View Publications||1|
|-||TP63 and Triple Negative Breast Cancer||View Publications||5|
Note: list is not exhaustive. Number of papers are based on searches of PubMed (click on topic title for arbitrary criteria used).
Disclaimer: This site is for educational purposes only; it can not be used in diagnosis or treatment.
Cite this page: Cotterill SJ. TP63, Cancer Genetics Web: http://www.cancer-genetics.org/TP63.htm Accessed:
This page in Cancer Genetics Web by Simon Cotterill is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
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[Home] Page last revised: 01 September, 2019 Cancer Genetics Web, Established 1999