|Gene:||TP63; tumor protein p63|
|Aliases:||AIS, KET, LMS, NBP, RHS, p40, p51, p63, EEC3, OFC8, p73H, p73L, SHFM4, TP53L, TP73L, p53CP, TP53CP, B(p51A), B(p51B)|
|Summary:||This gene encodes a member of the p53 family of transcription factors. An animal model, p63 -/- mice, has been useful in defining the role this protein plays in the development and maintenance of stratified epithelial tissues. p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3); split-hand/foot malformation 4 (SHFM4); ankyloblepharon-ectodermal defects-cleft lip/palate; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth); limb-mammary syndrome; Rap-Hodgkin syndrome (RHS); and orofacial cleft 8. Both alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different proteins. Many transcripts encoding different proteins have been reported but the biological validity and the full-length nature of these variants have not been determined. [provided by RefSeq, Jul 2008]|
|Databases:||OMIM, VEGA, HGNC, Ensembl, GeneCard, Gene|
|Protein:||tumor protein 63|
|Source:||NCBIAccessed: 25 June, 2015|
What does this gene/protein do?
Data table showing topics related to specific cancers and associated disorders. Scope includes mutations and abnormal protein expression.
|Head and Neck Cancers||TP63 and Head and Neck Cancers||View Publications||70|
|Lung Cancer||TP63 and Lung Cancer||View Publications||39|
|Breast Cancer||TP63 and Breast Cancer||View Publications||23|
Note: list is not exhaustive. Number of papers are based on searches of PubMed (click on topic title for arbitrary criteria used).
Disclaimer: This site is for educational purposes only; it can not be used in diagnosis or treatment.
Cite this page: Cotterill SJ. TP63, Cancer Genetics Web: http://www.cancer-genetics.org/TP63.htm Accessed:
This page in Cancer Genetics Web by Simon Cotterill is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
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[Home] Page last revised: 25 June, 2015 Cancer Genetics Web, Established 1999