|Gene:||CLP1; cleavage and polyadenylation factor I subunit 1|
|Summary:||This gene encodes a member of the Clp1 family. The encoded protein is a multifunctional kinase which is a component of the tRNA splicing endonuclease complex and a component of the pre-mRNA cleavage complex II. This protein is implicated in tRNA, mRNA, and siRNA maturation. Mutations in this gene are associated with pontocerebellar hypoplasia type 10 (PCH10). Alternatively splice transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]|
|Databases:||OMIM, VEGA, HGNC, Ensembl, GeneCard, Gene|
|Protein:||polyribonucleotide 5'-hydroxyl-kinase Clp1|
|Source:||NCBIAccessed: 18 March, 2015|
Mouse over the terms for more detail; many indicate links which you can click for dedicated pages about the topic.
Data table showing topics related to specific cancers and associated disorders. Scope includes mutations and abnormal protein expression.
|-||CLP1 and Germinoma||View Publications||1|
|Brain and CNS Tumours||CLP1 and Brain and CNS Tumours||View Publications||1|
|Testicular Cancer||CLP1 and Testicular Cancer||View Publications||1|
|Brain Stem Glioma, Childhood||CLP1 and Brain Stem Glioma, Childhood||View Publications||1|
Note: list is not exhaustive. Number of papers are based on searches of PubMed (click on topic title for arbitrary criteria used).
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Cite this page: Cotterill SJ. HEAB gene, Cancer Genetics Web: http://www.cancer-genetics.org/HEAB.htm Accessed:
This page in Cancer Genetics Web by Simon Cotterill is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
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[Home] Page last revised: 18 March, 2015 Cancer Genetics Web, Established 1999